Biochemical and structural analyses suggest that plasminogen activators coevolved with their cognate protein substrates and inhibitors
نویسندگان
چکیده
منابع مشابه
Plasminogen activators and plasminogen activator inhibitors in endometriosis.
Endometriosis is one of the most frequent benign gynecological diseases that affect women. Little is known about the pathogenesis and etiology of endometriosis, despite the numerous studies performed in this field. Although endometriosis is a benign disease, the endometrial tissue, after attachment to the peritoneum, has the ability to grow and invade the surrounding tissues. Similar to neoplas...
متن کاملRegulation and Secretion of Plasminogen Activators and Their Inhibitors in a Human Leukemic Cell
The secretion of tissue plasminogen activator ft-PA). urokinase (u-PA) and their inhibitors by the human leukemia cell line K562 was examined. K562 cells normally secrete both t -PA and u-PA in a ratio of 3:1 . After addition of 10 or 1 ng/mL phorbol myristate acetate (PMA) to K562 cells. a marked decrease in enzymatic activity is observed in the medium. However. when t-PA antigen rather than a...
متن کاملPlasminogen activators and their inhibitors in synovial fluids from normal, osteoarthritis, and rheumatoid arthritis knees.
OBJECTIVES To establish baseline concentrations of plasminogen activators and their inhibitors in normal knee synovial fluids, and to compare them with well characterised osteoarthritis (OA) and rheumatoid arthritis (RA) knee fluids. METHODS A total of 26 normal subjects, 71 patients with OA, and 17 patients with RA underwent knee aspiration. Patients with OA were subclassified according to p...
متن کاملRegulation and secretion of plasminogen activators and their inhibitors in a human leukemic cell line (K562).
The secretion of tissue plasminogen activator (t-PA), urokinase (u-PA) and their inhibitors by the human leukemia cell line K562 was examined. K562 cells normally secrete both t-PA and u-PA in a ratio of 3:1. After addition of 10 or 1 ng/mL phorbol myristate acetate (PMA) to K562 cells, a marked decrease in enzymatic activity is observed in the medium. However, when t-PA antigen rather than act...
متن کاملevolutionary origin and phylogenetic relationships among fusarium oxysporum f. sp. melonis isolates in iran and their relationship with nonpathogenic isolates
پژمردگی فوزاریومی خربزه و طالبی با عامل fusarium oxysporum f. sp. melonis از بیماری های مهم قارچی در مناطق رشد این گیاهان می باشد. جدایه های f. oxysporum از گیاهان و خاک ریزوسفر متعلق به پنج استان مهم تولیدکننده ی خربزه و طالبی جداسازی شد و بر پایه ی بیماری زایی در ارقام افتراقی، گروه های سازگاری رویشی (vegetative compatibility groups)، توالی سنجی ناحیه ی جداکننده ی بین ژنی دی اِن اِی ریبوزومی (n...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2019
ISSN: 0021-9258
DOI: 10.1074/jbc.ra118.005419